Editorial .......................................................................................... 1

Přehledné články

Rudolf Kotas
Antiepileptika v profylaxi migrény ...................................................... 8
Jolana Marková
Bolest hlavy jako akutní stav v neurologii ......................................... 14
Jan Procházka
Má off-label léčba význam pro rozvoj léčebných postupů? ..................18
Marta Kulichová
Kontrola nádorovej bolesti obtiažne reagujúcej
na systémovú liečbu opioidmi ........................................................ 24

Původní práce

Jana Kluknavská, Marta Kulichová
Výhody a limitácie transdermálneho
buprenorfínu – naše doterajšie skúsenosti ...................................... 28

Igor Otáhal, Karel Pelikán, Pavel Ševčík
Perioperační analgezie pro operace hypospadie dětí ........................ 31

Historie bolesti

Ivan Vrba
Vývoj regionální anestezie
na konci 19. století a ve 20. století ................................................. 37

Dopis redakci ............................................................................... 41

Zprávy ......................................................................................... 42

Informace .................................................................................... 44

Rejstříky ..................................................................................... 46

Editorial ........................................................................................ 1

Reviews

Rudolf Kotas
Antiepileptic drugs in the prevention of migraine ................................ 8
Jolana Marková
Headache as an emergency in Neurology ....................................... 14
Jan Procházka
Has off-label therapy an implication for the development
of therapeutical progress? ..............................................................18
Marta Kulichová
The management of cancer pain which has poorly
responsiveness to systemic opioid therapy ..................................... 24

Original papers

Jana Kluknavská, Marta Kulichová
Advantages and limitations of transdermal application
of buprenorfphine – our experiences ............................................... 28

Igor Otáhal, Karel Pelikán, Pavel Ševčík
Perioperative analgesia for hypospadia repairs in the children ........... 31

History of Pain

Ivan Vrba
Evolution of regional anesthesia in the late 19th century
and in the 20th century ................................................................. 37

Letter to the Editor ....................................................................... 41

News .......................................................................................... 42

Informations ................................................................................ 44

Indexes....................................................................................... 46