OBSAH Editorial Richard Rokyta ................................................................................................................................. 1 Obsah .......................................................................................................,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,........ 3 Původní práce – kazuistika Petr Cvrček Obtížně řešitelná postherpetická neuralgie – kazuistika ............................................................. 7 Přehledné články Tomáš Nežádal Migréna – současné možnosti terapie ................................................................................. 12 Ivan Vrba, Jiří Kozák Opioidy vyvolaná obstipace – nové možnosti léčby .................................................... 21 Edvard Ehler Bolestivá diabetická neuropatie ............................................................................................... 29 Karel Nesměrák Historický vývoj anestetik ................................................................................................... 32 CONTENT Editorial Richard Rokyta ............................................................................................................................... 1 Content ......................................................................................................................................................... 3 Original paper – case report Petr Cvrček Intractable postherpetic neuralgia – case report ....................................................................... 7 Reviews Tomáš Nežádal Migraine – current treatment options ................................................................................. 12 Ivan Vrba, Jiří Kozák Opioid-induced constipation – new treatment possibilities ......................................... 21 Edvard Ehler Painful diabetic neuropathy .................................................................................................... 29 Karel Nesměrák Historical development of anesthetics ............................................................................... 32