Tigis

OBSAH

EDITORIAL
Pavlína Králíčková, Irena Krčmová ................................................................ 1

OBSAH ........................................................................................................ 5

PROGRAM ................................................................................................. 8

ABSTRAKTY

Klinické aspekty laboratorní diagnostiky v alergologii................................... 18

Potravinové alergie a intolerance.................................................................. 19

Bronchiální astma ......................................................................................... 21

Laboratorní diagnostika v klinické imunologii................................................ 23

Alergie na hmyzí jedy.................................................................................... 26

Spojené cesty alergoimunologa a gastroenterologa..................................... 28

Komplement a jeho poruchy.......................................................................... 30

Transplantační imunologie............................................................................. 34

Získané poruchy imunity................................................................................ 37

Antiinfekční imunita a vakcinace .................................................................. 40

Spojené cesty alergologa a ORL lékaře ....................................................... 42

Novinky v léčbě autoimunitních onemocnění ............................................... 45

Sekce imunologických laborantů................................................................... 47

Lékové hypersenzitivity.................................................................................. 48

Inhalační alergeny a alergenová terapie........................................................ 50

Vrozené poruchy imunity................................................................................. 54

Sesterská sekce.............................................................................................. 57

Novinky v nádorové imunologii a imunoterapii................................................ 60

Spojené cesty alergologa a dermatologa........................................................ 62

Funkční diagnostické testy v respiračních chorobách .................................... 67

Mladí alergologové a imunologové ................................................................. 69

Mastocytární onemocnění................................................................................ 73

Imunologicky podmíněné poruchy plodnosti ................................................... 74

Neuroimunologie ............................................................................................. 76

Interakce imunitního systému s mikroby.......................................................... 77

POSTEROVÁ SEKCE I................................................................................... 80

POSTEROVÁ SEKCE II. ................................................................................ 87

REJSTŘÍK AUTORŮ ...................................................................................... 95

 

CONTENTS

EDITORIAL
Pavlína Králíčková, Irena Krčmová ................................................................. 1

CONTENTS................................................................................................. 5

PROGRAMME ........................................................................................... 8

ABSTRACTS

Clinical aspects of laboratory diagnostics in allergology............................... 18

Food allergies and intolerances.................................................................... 19

Bronchial asthma ......................................................................................... 21

Laboratory diagnostics in clinical immunology.............................................. 23

Allergy to insect venoms............................................................................... 26

Joint trips of an allergist and a gastroenterologist......................................... 28

Complement and its disorders...................................................................... 30

Transplantation immunology......................................................................... 34

Acquired immunity disorders ........................................................................ 37

Anti-infective immunity and vaccination ....................................................... 40

Joint trips of an allergist and an ENT doctor ................................................ 42

New developments in the treatment of autoimmune diseases .................... 45

Section of immunological laboratory technicians.......................................... 47

Drug hypersensitivities ................................................................................. 48

Inhaled allergens and allergen therapy......................................................... 50

Congenital immune disorders ...................................................................... 54

Nurse section ............................................................................................... 57

New developments in cancer immunology and immunotherapy................... 60

Joint trips of an allergist and a dermatologist ............................................... 62

Functional diagnostic tests in respiratory diseases ...................................... 67

Young allergologists and immunologists ...................................................... 69

Mastocytic disease ....................................................................................... 73

Immunologically conditioned fertility disorders ............................................. 74

Neuroimmunology ........................................................................................ 76

Interaction of the immune system with microbes.......................................... 77

POSTERS I. ................................................................................................. 80

POSTERS II. ................................................................................................ 87

INDEX .......................................................................................................... 95

OBSAH

EDITORIAL......................................................................................................................... 105

DIABETOLOGIE

Juraj Gmitrov
Význam nových inzulínov a ich kombinácií s GLP-1 agonistami
a SGLT-2 inhibítormi v svetle patofyziologického prístupu
k liečbe diabetu 2. typu..........................................................................................................112

Fejfarová Vladimíra, Piťhová Pavlína, Jirkovská Alexandra, Koliba Miroslav,
Jirkovská Jarmila, Kůsová Hana, Sixta Bedřich
Činnost podiatrie ve světle posledních let.............................................................................123

ENDOKRINOLOGIE

Tereza Grimmichová, Jaromír Astl, Jan Kaván, Svatopluk Smutný, Jan Jiskra
Minimálně invazivní ablační techniky uzlů štítné žlázy...........................................................129

Michaela Svojtková (Dušková)
Jaký je vliv typu diety na koncentraci testosteronu?...............................................................136

INFORMACE

Jiří Zeman, Jakub Vysloužil, Jan Elbl, Sylvie Pavloková
Komparativní analýza gastroretentivních vlastností a disolučních
profilů originálních a generických tablet s prodlouženým
uvolňováním metforminu........................................................................................................145

ZPRÁVY

Česká diabetologická společnost ČLS JEP. Zpráva ze zasedání Výboru............................ 152

AKCE

Plánované domácí a mezinárodní akce............................................................................... 153

CONTENTS

EDITORIAL....................................................................................................................... 105

DIABETOLOGY

Juraj Gmitrov
The importance of the novel insulins and their combinations
with GLP-1 agonists and SGLT2 inhibitors in the light of the
pathophysiological approach to treat type 2 diabetes ...........................................................112

Fejfarová Vladimíra, Piťhová Pavlína, Jirkovská Alexandra, Koliba Miroslav,
Jirkovská Jarmila, Kůsová Hana, Sixta Bedřich
The activities of czech podiatry in the light of recent years....................................................123

ENDOCRINOLOGY

Tereza Grimmichová, Jaromír Astl, Jan Kaván, Svatopluk Smutný, Jan Jiskra
Minimally invasive techniques for thyroid nodules..................................................................129

Michaela Svojtková (Dušková)
What is the effect of the type of diet on testosterone concentrations?....................................136

INFORMATION

Jiří Zeman, Jakub Vysloužil, Jan Elbl, Sylvie Pavloková
Comparative analysis of gastroretentive properties and dissolution
profiles of original and generic metformin extended-release tablets........................................145

NEWS

Czech Diabetes Society – report from the Committee Meeting .............................................. 152

FUTURE EVENTS

Planned domestic and international events.............................................................................. 153

OBSAH

EDITORIAL

Richard Balon.......................................................................................................................... 85

OBSAH..................................................................................................................................87

PŘEHLEDNÉ ČLÁNKY

Veronika Juríčková, Ladislav Kesner, Dominika Grygarová, Jiří Horáček
Současné možnosti remediace negativních dopadů mediálních zpráv
na duševní zdraví................................................................................................................... 89

Kamila Zvolská, Eva Králíková
Přehlížená diskrepance: zdravý životní styl a kouření............................................................ 95

Jiří Patočka, Zdeňka Navrátilová, Kamil Kuča, Bohumír Plucar
Biologicky účinné metabolity kotrče kadeřavého.................................................................... 99

KAZUISTIKY

Jonáš Boček
Psychotické stavy u pacientů po prodělání covidu-19: série kazuistik.................................. 103

FÓRUM ČESKÉ NEUROPSYCHOFARMAKOLOGICKÉ SPOLEČNOSTI

Miloslav Kopeček, Jiří Masopust
Dlouhodobě působící injekční intramuskulární aripiprazol
aplikovaný jednou za 2 měsíce je připraven k použití............................................................ 108

ZPRÁVY

Pavel Doubek
Druhé Podzimní sympozium České neuropsychofarmakologické společnosti....................... 113

Vanda Franková
Inhibitory acetylcholinesterázy – nová pravidla
úhrady ze zdravotního pojištění............................................................................................... 114

DOPISY, OHLASY, DISKUSE

Cyril Höschl, Filip Španiel
Umění a (neuro)věda.............................................................................................................. 116

Miloslav Kopeček
Orální aplikace ketaminu v tabletách s prodlouženým uvolněním (R-107) byla
efektivní v multicentrické, dvojitě zaslepené, placebem kontrolované studii typu
2 u pacientů s rezistentní depresivní poruchou. Studie BEDROC..........................................124

Pavla Doležalová, Anna Lorenzová
Standardy péče o zdraví transgender a genderově rozmanitých osob,
verze č. 8 
(SOC-8)...................................................................................................................126

POKYNY AUTORŮM....................................................................................................... 128

CONTENTS

EDITORIAL

Richard Balon........................................................................................................................... 85

CONTENTS...........................................................................................................................87

ORIGINAL PAPERS

Veronika Juríčková, Ladislav Kesner, Dominika Grygarová, Jiří Horáček
Current possibilieties for remediation of the negative effects of media news on
mental health............................................................................................................................ 89

Kamila Zvolská, Eva Králíková
An overlooked discrepancy: healthy lifestyle and smoking....................................................... 95

Jiří Patočka, Zdeňka Navrátilová, Kamil Kuča, Bohumír Plucar
Biologically active metabolites of the cauliflower mushroom..................................................... 99

CASE STUDIES

Jonáš Boček
Psychotic conditions among patients in the aftermath of COVID-19:
case histories .......................................................................................................................... 103

FORUM OF THE CZECH NEUROPSYCHOPHARMACOLOGICAL SOCIETY

Miloslav Kopeček, Jiří Masopust
Long-acting injectable intramuscular aripiprazol ready-to-use
every 2 months........................................................................................................................ 108

NEWS

Pavel Doubek
Second Autumn Symposium of the Czech Neuropsychopharmacological Society...................113

Vanda Franková
Acetylcholinesterase inhibitors – new health insurance reimbursement rules.......................... 114

CORRESPONDENCE

Cyril Höschl, Filip Španiel
Arts and Neuroscience – Encounters........................................................................................ 116

Miloslav Kopeček
BEDROC study: Extended-release, oral ketamine (R-107) was effective
in multicenter, randomized, placebo-controlled, phase 2 study in patients
with treatment-resistant major depression..................................................................................124

Pavla Doležalová, Anna Lorenzová
Standards of Care for the Health of Transgender and Gender Diverse People,
Version 8......................................................................................................................................126

INSTRUCTIONS FOR AUTHORS................................................................................... 128

OBSAH

Editorial .................................................................................................. 65

Obsah .................................................................................................... 69

Přehledné články

Předoperační příprava dialyzovaných pacientů
Jan Vachek, Kateřina Oulehle,
Oskar Zakiyanov, Vladimír Tesař
........................................................... 72

Přehledné články

Akutní poškození ledvin v klinické medicíně
Nadežda Petejová, Josef Zadražil, Arnošt Martínek .............................. 79

Předplatné............................................................................................. 99

Pokyny autorům................................................................................. 100

 

CONTENTS

Editorial ................................................................................................... 65

Contents .................................................................................................. 69

Reviews

Preoperative preparation of dialysis patients
Jan Vachek, Kateřina Oulehle,
Oskar Zakiyanov, Vladimír Tesař .............................................................. 72

Reviews

Acute kidney injury in clinical medicine
Nadežda Petejová, Josef Zadražil, Arnošt Martínek ................................. 79

Journal subscription ............................................................................... 99

Instruction for authors ........................................................................... 100

OBSAH

Editorial
Richard Rokyta ........................................................................................................ 89

Obsah ................................................................................................................... 91

Původní práce

Jiří Málek
Kratom a jeho význam v algeziologii ....................................................................... 94

Přehledné články

Olga Šléglová
Úloha algeziologa v současné strategii léčby
revmatoidní artritidy ................................................................................................ 101

Přehledné články - kazuistiky

Markéta Sykáčková, Martin Jíra
Calcitonin gene-related peptid a cílená léčba migrény ........................................... 109

Veronika Zachová
Stomie není jediná bolest pacienta ......................................................................... 114

Přehledné články

Pavla Slivková
Pohybová terapie jako nástroj ke zlepšení kvality života
onkologicky nemocných ........................................................................................... 118

Rozhovor
Profesor Stefan Friedrichsdorf ................................................................................. 125

Zprávy

World Congress on Pain IASP (International Association
of the Study of Pain) Amsterodam 2024 .................................................................. 128

Informace

Kalendář vědeckých akcí .......................................................................................... 133

Pokyny autorům ................................................................................................ 135

Předplatné ............................................................................................................ 136

 

CONTENT

 

Editorial
Richard Rokyta ........................................................................................................... 89

Content ...................................................................................................................... 91

Original paper

Jiří Málek
Kratom and its implication in algesiology .................................................................... 94

Reviews

Olga Šléglová
The role of the algesiologist in the current strategy
for the treatment of rheumatoid arthritis ...................................................................... 101

Reviews - case report

Markéta Sykáčková, Martin Jíra
Calcitonin gene related peptide and targeted
treatment of migraine ................................................................................................... 109

Veronika Zachová
The stoma isn‘t only one pain of ostomy patients ......................................................... 114

Reviews

Pavla Slivková
Movement therapy as a tool to improve quality of life
of cancer patients .......................................................................................................... 118

Interview

Professor Stefan Friedrichsdorf ..................................................................................... 125

News

World Congress on Pain IASP (International Association
of the Study of Pain) Amsterodam 2024 ......................................................................... 128

Informations

Scientific Events Calendar .............................................................................................. 133

Instruction for authors ..................................................................................................... 135

Journal subscription ........................................................................................................ 136

OBSAH

INFORMACE

Česká asociace veterinárních lékařů malých zvířat ................................................................... 138

Slovenská asociácia veterinárnych lekárov malých zvierat ........................................................ 140

EDITORIAL
Roman Kvapil.............................................................................................................................. 142

OBSAH....................................................................................................................................... 145

PŮVODNÍ ČLÁNKY

Nutriční management idiopatické epilepsie u psů
Eva Štercová................................................................................................................................ 151

Když se řekne škrkavky
Lada Hofmannová ...................................................................................................................... 164

Je idiopatická cystitida skutečně idiopatická?
Simona Kovaříková ..................................................................................................................... 169

ABSTRAKTY ZE ZAHRANIČNÍCH ČASOPISŮ......................................................................... 180
The Veterinary Clinics of North America. Small Animal Practice,
Veterinary Surgery, Veterinary Dermatology, Veterinary Ophthalmology,
Reproduction in Domestic Animals = Zuchthygiene, Journal of Veterinary
Emergency and Critical Care, American Journal of Veterinary Research,
Journal of Veterinary Cardiology

FOTOGALERIE

Ulcerativní a proliferativní změny sliznice dutiny ústní u koček
Vladěna Stránská ........................................................................................................................ 185

ZPRÁVY

Státní veterinární správa ČR
ČR získala nově status země prosté plicní nákazy skotu,
je znovu také zemí prostou ptačí chřipky
Petr Majer.................................................................................................................................... 192

ČR je již dvacet let oficiálně zemí bez výskytu vztekliny
Petr Vorlíček ............................................................................................................................... 193

Český svaz ochránců přírody
Mláďata rorýse obecného v záchranných stanicích
Petr N. Stýblo............................................................................................................................... 196

Zoo Praha
Bércoun Petersův (Rhynchocyon Petersi) – prvoodchov v Zoo Praha, resp. v ČR
Roman Vodička, Martina Marešová ............................................................................................. 201

KLINICKO-PATOLOGICKÉ KAZUISTIKY

Tumory žaludku u psů z hlediska bioptické diagnostiky
František Jelínek .......................................................................................................................... 204

POKYNY AUTORŮM ................................................................................................................... 208

 

CONTENTS

INFORMATION

Czech small animal veterinary association..................................................................................... 138

Slovak small animal veterinary association..................................................................................... 140

EDITORIAL
Roman Kvapil................................................................................................................................... 142

CONTENTS...................................................................................................................................... 145

ORIGINAL PAPERS

Nutritional management of idiopathic epilepsy in dogs
Eva Štercová......................................................................................................................................151

When you say round worms
Lada Hofmannová ............................................................................................................................ 164

Is feline idiopathic cystitis truly idiopathic?
Simona Kovaříková ........................................................................................................................... 169

ABSTRACTS FROM FOREIGN JOURNALS.................................................................................... 180
The Veterinary Clinics of North America. Small Animal Practice,
Veterinary Surgery, Veterinary Dermatology, Veterinary Ophthalmology,
Reproduction in Domestic Animals = Zuchthygiene, Journal of Veterinary
Emergency and Critical Care, American Journal of Veterinary Research,
Journal of Veterinary Cardiology

PHOTOGALLERY

Ulcerative and proliferative changes of the oral mucosa in cats
Vladěna Stránská ................................................................................................................................. 185

NEWS

State veterinary management
The Czech Republic has now been granted the status of a country free of bovine
pleuropneumonia, it is also once again a country free of avian influenza
Petr Majer................................................................................................................................................ 192

The Czech Republic has been officially a rabies-free country for twenty years
Petr Vorlíček ............................................................................................................................................ 193

Czech Association of the nature
Rorys juveniles in rescue stations
Petr N. Stýblo............................................................................................................................................. 196

Zoo Praha
The black and rufous sengi (Rhynchocyon Petersi) – first breed in Prague Zoo,
respectively in the Czech Republic
Roman Vodička, Martina Marešová ............................................................................................................ 201

CLINICOPATHOLOGICAL CASE REPORTS

Tumors of the stomach of dogs from the aspect of bioptic diagnostics
František Jelínek .......................................................................................................................................... 204

INSTRUCTIONS TO AUTHORS .................................................................................................................. 208

pondělí, 09 září 2024 10:55

Alergie_3_2024

Napsal(a)

OBSAH

EDITORIAL
Dalibor Jílek ........................................................................................ 133

SPOLEČENSKÉ UDÁLOSTI V ČSAKI ...............................................134

PŮVODNÍ PRÁCE

Nové možnosti laboratorní diagnostiky lymeské boreliózy pomocí
multiplexových technik
Kateřina Bufková..................................................................................145

PŘEHLEDNÉ ČLÁNKY

Dermatitidy asociované s Helicobacter pylori
Jana Konečná.......................................................................................153

Potraviny jako nástroj pro podporu imunity
Iveta Klojdová........................................................................................157

KAZUISTIKY

Inflamatorní myofibroblastický tumor hrtanu – opoždění diagnózy
záměnou za bronchiální astma
Michal Jurovčík, Manuela Bodláková, Zdeněk Čada.............................163

TERAPIE

Alergénová imunoterapia ako prostriedok k redukcii respiračnej
chorobnosti u detských roztočových alergikov
Peter Kunč, Jaroslav Fábry, Daniel Lúčaník,
Michaela Matiščáková
...........................................................................167

Imunoterapie hmyzími jedy v otázkách a odpovědích – kapesní manuál
(1. část: Indikace a kontraindikace imunoterapie hmyzími jedy)
Martina Vachová, Petr Kučera..............................................................175

Alergenová imunoterapie u alergií na pyl stromů
Daniela Potyszová................................................................................183

KONFERENCE, KONGRESY...............................................................187

INFORMACE

Přehled akcí ČSAKI na rok 2024 ....................................................... 193

POKYNY AUTORŮM ........................................................................... 195

PŘEDPLATNÉ .......................................................................................196

 

CONTENTS

 

EDITORIAL
Dalibor Jílek .......................................................................................... 133

SOCIAL EVENTS IN THE CSAKI ...................................................... 134

ORIGINAL PAPERS

New options for laboratory diagnosis of Lyme disease using multiplex
techniques
Kateřina Bufková..................................................................................145

REVIEWS

Dermatitis associated with Helicobacter pylori
Jana Konečná......................................................................................153

Food as a tool for immunity support
Iveta Klojdová.......................................................................................157

CASE REPORT

Inflammatory myofibroblastic tumor of the larynx –
delayded diagnosis
due to mimicking bronchial asthma
Michal Jurovčík, Manuela Bodláková, Zdeněk Čada............................163

TERAPIE

Employing allergen immunotherapy for the mitigation of respiratory
morbidity in pediatric patients with dust mite allergies
Peter Kunč, Jaroslav Fábry, Daniel Lúčaník,
Michaela Matiščáková
...........................................................................167

Venom immunotherapy in questions and answers – a pocket guide
(1. part: Indications and contraindications of venom immunotherapy)
Martina Vachová, Petr Kučera..............................................................175

Allergen immunotherapy in tree pollen allergies
Daniela Potyszová................................................................................183

CONFERENCE, CONGRESS .............................................................187

INFORMATION

Future events 2024 ...............................................................................193

INSTRUCTION FOR AUTHORS ..........................................................195

SUBSCRIPTION ...................................................................................196

OBSAH 

Editorial
Ester Seberová................................................................................................................ 1

Obsah ............................................................................................................................3

Aktuální téma

Očkování proti chřipce
Jan Kynčl......................................................................................................................... 5

Dýchací cesty

Nemoci z nachlazení z pohledu imunologa. Je potřeba ovlivňovat
imunitu v dětském věku? 2. část
Jaromír Bystroň................................................................................................................ 9

Zánět středního ucha
Jiří Havránek...................................................................................................................14

Prostředí a alergik

Jak se bránit před roztočovou a pylovou alergií
Jana Emlerová................................................................................................................19

Kůže

Přínos lázeňské léčby v léčbě kožních nemocí
Alice Müllerová...............................................................................................................21

Lázně a rehabilitace

Blahodárné účinky lzeňské léčby
Dana Šašková................................................................................................................25

Příběhy z ambulance

Deficit alfa 1 antitrypsinu – problém,
který má svou příčinu i řešení
Lenka Brožová................................................................................................................34

 

Foto na titulní straně: ©lopolo/123RF

OBSAH

EDITORIAL
Martin Fuchs ............................................................................................ 1

DIAGNOSTIKA IgE MEDIOVANÉ POTRAVINOVÉ ALERGIE
Simona Bělohlávková, Martin Fuchs, Milena Jeřábková, Martin Liška,
Jana Novobílská, Daniela Potyszová, Ivana Šetinová,
Eva Švarcová.............................................................................................7

Alergie na bílkoviny kravského mléka......................................................10

Alergie na vejce........................................................................................13

Alergie na ryby.........................................................................................14

Alergie na korýše a měkkýše ..................................................................17

Jedlý hmyz...............................................................................................19

Alergie na maso (sérové albuminy a alfa-gal)..........................................20

Alergie na pšeničnou mouku....................................................................22

Alergie na pohanku...................................................................................24

Alergie na ořechy a semena.....................................................................24

Zásobní proteiny semen...........................................................................27

Oleosiny ...................................................................................................29

Alergie na arašíd ......................................................................................30

Alergie na sóju .........................................................................................32

Alergie na ovoce a zeleninu......................................................................32

PR-10-like alergeny (Bet v 1 homologní alergeny)................................... 36

Profiliny......................................................................................................38

.LTP – lipid transfer proteiny......................................................................38

Gibberellin-regulated proteiny................................................................... 41

Závěr..........................................................................................................41

 

CONTENTS

EDITORIAL
Martin Fuchs ............................................................................................. 1

DIAGNOSIS OF IgE MEDIATED FOOD ALLERGY
Simona Bělohlávková, Martin Fuchs, Milena Jeřábková, Martin Liška,
Jana Novobílská, Daniela Potyszová, Ivana Šetinová,`
Eva Švarcová............................................................................................7

Cow‘s milk allergy....................................................................................10

Allergy to egg...........................................................................................13

Allergy to fish...........................................................................................14

Allergies to crustaceans and molluscs ...................................................17

Edible insects..........................................................................................19

Allergy to meat (serum albumins and alpha-gal).....................................20

Wheat allergy...........................................................................................22

Buckwheat allergy....................................................................................24

Tree nut and seed allergy........................................................................24

Seed storage proteins.............................................................................27

Oleosins .................................................................................................29

.Peanut allergy .......................................................................................30

Soy allergy .............................................................................................32

Fruit and vegetable allergy.....................................................................32

PR-10-like allergens.............................................................................. 36

Profilins...................................................................................................38

LTP - lipid transfer proteins.....................................................................38

Gibberellin-regulated proteins................................................................ 41

Conclusion...............................................................................................41

OBSAH

Editorial .............................................................................................................. 1

Pokyny autorům ................................................................................................. 3

Přehledné články

Kapšová K., Dukonyová D., Beňuš R., Kyselicová K.
Kandidátne gény pre autizmus vo vzťahu k fyziológii
a patofyziológii formovania odtlačkov prstov ...................................................... 6

Javorka K.
Prínos rodákov zo súčasných území Česka a Slovenska
na vývoji metód merania tlaku krvi .................................................................... 11

Cendelín J., Purkartová Z.
Buněčná terapie mozečkových onemocnění .................................................... 18

Zprávy ............................................................................................................... 23

 

CONTENTS

 Editorial .............................................................................................................. 1

Instructions for authors ........................................................................................ 3

Reviews

Kapšová K., Dukonyová D., Beňuš R., Kyselicová K.
Candidate genes for autism in relation to the physiology
and pathophysiology of fingerprint formation ...................................................... 6

Javorka K.
Contribution of natives of the present territories of the
Czech Republic and Slovakia to the development
of blood pressure measurement methods ......................................................... 11

Cendelín J., Purkartová Z.
Cell therapy for cerebellar diseases .................................................................. 18

News .................................................................................................................. 23

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